Abstract: In recent years, the epidemiological community has been insistent in its warnings about the significant increase of drug resistance among bacterial and fungal strains. MDROs, i.e. multi-drug resistant strains insensitive to antibiotics from three or more classes of antibacterial drugs active against a given species of microorganisms, are a time bomb, because they do not always give clinical symptoms – in carriers they can be asymptomatic. Without implementing measures to prevent the spread of these microorganisms in the local population, we are heading towards Armageddon. Action strategies in the area of preventing the spread of these strains should be multilevel – from activities at the ministerial level through the decision-making of hospital managers, to the personal involvement of each healthcare worker and patient.

Key words: hospital infection, multidrug-resistant organisms, prevention